AK9

adenylate kinase 9 | FLJ25791, FLJ42177, MGC26954, dJ70A9.1, AKD1, AKD2, C6orf199, C6orf224

The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. [provided by RefSeq, Jul 2016]

Biological processes 28 terms

AMP kinase activity (GO:0004017)ATP binding (GO:0005524)CDP biosynthetic process (GO:0046705)CMP kinase activity (GO:0036430)UDP biosynthetic process (GO:0006225)UMP kinase activity (GO:0033862)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)dAMP kinase activity (GO:0047506)dCMP kinase activity (GO:0036431)motile cilium (GO:0031514)nuclear membrane (GO:0031965)nucleobase-containing compound kinase activity (GO:0019205)nucleoplasm (GO:0005654)nucleoside diphosphate kinase activity (GO:0004550)nucleoside diphosphate kinase activity (GO:0004550)nucleoside diphosphate kinase activity (GO:0004550)nucleoside monophosphate kinase activity (GO:0050145)nucleoside monophosphate kinase activity (GO:0050145)nucleoside monophosphate metabolic process (GO:0009123)nucleotide metabolic process (GO:0009117)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)phosphotransferase activity, phosphate group as acceptor (GO:0016776)

Expression (TPM)

TFs regulating AK9 0 TFs

Transcription factors with Perturb-seq knockdown data for AK9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AK9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AK9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AK9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:109,440,119–109,441,745	249.8 kb	Distal (>10kb) Multiome	863
chr6:109,454,912–109,456,586	234.6 kb	Distal (>10kb) Multiome	733
chr6:109,482,359–109,484,058	207.1 kb	Distal (>10kb) Multiome	675
chr6:109,678,985–109,679,628	11.3 kb	Distal (>10kb) Multiome	55
chr6:109,690,198–109,691,786	723 bp	At TSS Multiome	761
chr6:109,855,571–109,856,389	165.4 kb	Distal (>10kb) Multiome	57
chr6:109,869,245–109,870,084	179.2 kb	Distal (>10kb) Multiome	41
chr6:109,944,347–109,945,486	254.7 kb	Distal (>10kb) Multiome	254
chr6:109,977,901–109,979,311	288.0 kb	Distal (>10kb) Multiome	637
chr6:110,039,510–110,040,377	349.2 kb	Distal (>10kb) Multiome HiCAR	368

Genome Browser

Genomic view of the AK9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.