The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for AIMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AIMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AIMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:106,303,016–106,304,360 | 12.7 kb | Distal (>10kb) Multiome | 141 | |
| chr4:106,310,336–106,310,630 | 5.9 kb | Proximal (<10kb) | 12 | |
| chr4:106,315,490–106,317,043 | 202 bp | At TSS Multiome | 903 | |
| chr4:106,321,972–106,322,424 | 5.5 kb | Proximal (<10kb) | 24 | |
| chr4:106,418,081–106,419,107 | 102.1 kb | Distal (>10kb) Multiome | 127 | |
| chr4:106,501,809–106,502,862 | 185.9 kb | Distal (>10kb) Multiome | 204 | |
| chr4:106,550,844–106,551,984 | 234.9 kb | Distal (>10kb) Multiome | 177 | |
| chr4:106,803,548–106,804,144 | 487.4 kb | Distal (>10kb) Multiome HiCAR | 105 |
Genomic view of the AIMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.