S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for AHCY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AHCY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AHCY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,111,659–34,113,028 | 191.1 kb | Distal (>10kb) Multiome | 1069 | |
| chr20:34,302,649–34,303,619 | 141 bp | At TSS Multiome | 1055 | |
| chr20:34,311,332–34,311,914 | 8.2 kb | Proximal (<10kb) Multiome | 577 | |
| chr20:34,312,547–34,313,008 | 9.5 kb | Proximal (<10kb) Multiome | 740 | |
| chr20:34,345,865–34,346,371 | 42.8 kb | Distal (>10kb) Multiome | 61 | |
| chr20:34,362,888–34,363,977 | 59.9 kb | Distal (>10kb) Multiome | 858 | |
| chr20:34,515,293–34,516,855 | 212.2 kb | Distal (>10kb) Multiome HiCAR | 1003 | |
| chr20:34,549,322–34,549,906 | 246.3 kb | Distal (>10kb) Multiome | 216 | |
| chr20:34,558,287–34,559,412 | 255.3 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the AHCY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.