This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AGPAT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGPAT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGPAT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:160,975,941–160,976,668 | 297.8 kb | Distal (>10kb) Multiome | 101 | |
| chr6:160,991,139–160,992,602 | 282.4 kb | Distal (>10kb) Multiome | 919 | |
| chr6:161,011,600–161,012,221 | 262.1 kb | Distal (>10kb) Multiome | 101 | |
| chr6:161,243,176–161,243,910 | 30.5 kb | Distal (>10kb) Multiome | 194 | |
| chr6:161,272,174–161,274,561 | 1.3 kb | Proximal (<10kb) Multiome | 687 | |
| chr6:161,313,538–161,314,398 | 39.7 kb | Distal (>10kb) Multiome | 36 | |
| chr6:161,353,186–161,353,642 | 79.4 kb | Distal (>10kb) Multiome | 143 |
Genomic view of the AGPAT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.