Enables metallocarboxypeptidase activity. Involved in protein side chain deglutamylation. Predicted to be located in cytosol. Predicted to be active in centriole and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AGBL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGBL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGBL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:134,779,110–134,780,363 | 207.0 kb | Distal (>10kb) Multiome | 408 | |
| chr7:134,890,877–134,892,305 | 95.0 kb | Distal (>10kb) Multiome | 673 | |
| chr7:134,986,110–134,987,248 | 52 bp | At TSS Multiome | 1029 | |
| chr7:134,991,313–134,992,342 | 4.8 kb | Proximal (<10kb) | 284 | |
| chr7:135,170,026–135,171,132 | 184.2 kb | Distal (>10kb) Multiome | 1132 | |
| chr7:135,210,700–135,212,153 | 225.1 kb | Distal (>10kb) Multiome | 729 |
Genomic view of the AGBL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.