Predicted to be located in several cellular components, including actin cytoskeleton; anchoring junction; and cell projection. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AFAP1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AFAP1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AFAP1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:149,030,812–149,031,369 | 240.6 kb | Distal (>10kb) Multiome | 108 | |
| chr5:149,062,583–149,063,591 | 208.6 kb | Distal (>10kb) Multiome | 405 | |
| chr5:149,141,133–149,142,388 | 130.3 kb | Distal (>10kb) Multiome | 659 | |
| chr5:149,264,564–149,265,053 | 7.0 kb | Proximal (<10kb) Multiome | 184 | |
| chr5:149,269,060–149,269,250 | 2.6 kb | Proximal (<10kb) | 169 | |
| chr5:149,271,306–149,272,588 | 5 bp | At TSS Multiome | 470 | |
| chr5:149,273,332–149,274,284 | 2.0 kb | Proximal (<10kb) Multiome | 77 | |
| chr5:149,344,876–149,346,055 | 73.6 kb | Distal (>10kb) Multiome | 998 | |
| chr5:149,357,500–149,358,624 | 86.1 kb | Distal (>10kb) Multiome | 674 | |
| chr5:149,367,315–149,368,054 | 95.8 kb | Distal (>10kb) Multiome | 450 | |
| chr5:149,371,224–149,371,844 | 99.7 kb | Distal (>10kb) Multiome | 189 | |
| chr5:149,381,769–149,382,370 | 110.2 kb | Distal (>10kb) Multiome | 395 | |
| chr5:149,402,230–149,402,797 | 130.6 kb | Distal (>10kb) Multiome | 18 | |
| chr5:149,550,938–149,552,144 | 279.7 kb | Distal (>10kb) Multiome | 1038 |
Genomic view of the AFAP1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.