This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for ADK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,873,847–73,875,246 | 276.6 kb | Distal (>10kb) Multiome | 654 | |
| chr10:73,906,669–73,907,201 | 244.3 kb | Distal (>10kb) Multiome | 417 | |
| chr10:73,910,388–73,911,812 | 240.1 kb | Distal (>10kb) Multiome | 486 | |
| chr10:73,965,730–73,966,725 | 185.0 kb | Distal (>10kb) Multiome | 552 | |
| chr10:73,994,650–73,995,392 | 156.1 kb | Distal (>10kb) Multiome | 69 | |
| chr10:73,997,294–73,999,626 | 153.3 kb | Distal (>10kb) Multiome | 964 | |
| chr10:74,150,306–74,151,881 | 34 bp | At TSS Multiome | 926 | |
| chr10:74,176,195–74,177,295 | 25.4 kb | Distal (>10kb) Multiome | 1072 | |
| chr10:75,058,930–75,059,944 | 908.3 kb | Distal (>10kb) Multiome HiCAR | 137 | |
| chr10:75,079,403–75,080,508 | 928.6 kb | Distal (>10kb) Multiome HiCAR | 189 | |
| chr10:75,099,885–75,100,763 | 948.9 kb | Distal (>10kb) Multiome HiCAR | 419 | |
| chr10:75,111,043–75,112,358 | 960.3 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr10:75,206,644–75,207,978 | 1056.3 kb | Distal (>10kb) Multiome HiCAR | 207 |
Genomic view of the ADK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.