This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for ADAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:75,432,825–75,434,426 | 189.7 kb | Distal (>10kb) Multiome | 1143 | |
| chr16:75,463,598–75,465,197 | 158.5 kb | Distal (>10kb) Multiome | 999 | |
| chr16:75,494,705–75,495,929 | 127.8 kb | Distal (>10kb) Multiome | 341 | |
| chr16:75,516,521–75,518,019 | 105.8 kb | Distal (>10kb) Multiome | 921 | |
| chr16:75,555,188–75,556,662 | 68.0 kb | Distal (>10kb) Multiome | 900 | |
| chr16:75,565,779–75,567,123 | 56.9 kb | Distal (>10kb) Multiome | 834 | |
| chr16:75,593,861–75,594,383 | 29.1 kb | Distal (>10kb) Multiome | 336 | |
| chr16:75,622,804–75,623,690 | 26 bp | At TSS Multiome | 852 | |
| chr16:75,624,919–75,625,137 | 1.7 kb | Proximal (<10kb) | 230 | |
| chr16:75,647,337–75,649,003 | 25.6 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:77,133,565–77,134,646 | 1510.7 kb | Distal (>10kb) Multiome HiCAR | 131 | |
| chr16:77,190,160–77,191,630 | 1567.6 kb | Distal (>10kb) Multiome HiCAR | 915 | |
| chr16:77,211,464–77,213,653 | 1589.1 kb | Distal (>10kb) Multiome HiCAR | 644 |
Genomic view of the ADAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.