This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:130,146,013–130,146,727 | 282.1 kb | Distal (>10kb) Multiome | 413 | |
| chr11:130,159,259–130,160,341 | 268.8 kb | Distal (>10kb) Multiome | 309 | |
| chr11:130,212,937–130,213,600 | 215.3 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr11:130,314,035–130,315,987 | 113.8 kb | Distal (>10kb) Multiome | 766 | |
| chr11:130,378,066–130,378,569 | 50.2 kb | Distal (>10kb) Multiome | 64 | |
| chr11:130,383,295–130,383,854 | 45.0 kb | Distal (>10kb) Multiome HiCAR | 272 | |
| chr11:130,423,717–130,424,508 | 4.6 kb | Proximal (<10kb) Multiome | 77 | |
| chr11:130,427,546–130,428,649 | 347 bp | At TSS Multiome | 234 | |
| chr11:130,431,300–130,431,674 | 2.7 kb | Proximal (<10kb) | 157 | |
| chr11:130,434,543–130,435,226 | 5.9 kb | Proximal (<10kb) | 440 | |
| chr11:130,448,217–130,449,643 | 20.0 kb | Distal (>10kb) Multiome | 449 | |
| chr11:130,449,732–130,450,570 | 21.6 kb | Distal (>10kb) Multiome | 212 | |
| chr11:130,560,154–130,560,797 | 131.8 kb | Distal (>10kb) Multiome | 124 | |
| chr11:130,827,628–130,828,316 | 399.3 kb | Distal (>10kb) Multiome HiCAR | 244 | |
| chr11:130,861,810–130,862,310 | 433.5 kb | Distal (>10kb) Multiome HiCAR | 489 | |
| chr11:130,876,155–130,876,673 | 447.8 kb | Distal (>10kb) Multiome HiCAR | 26 | |
| chr11:130,916,036–130,916,933 | 487.9 kb | Distal (>10kb) Multiome HiCAR | 639 |
Genomic view of the ADAMTS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.