This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADAMTS19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:129,458,928–129,459,047 | 1.2 kb | Proximal (<10kb) | 50 | |
| chr5:129,459,148–129,462,168 | 504 bp | At TSS Multiome | 611 | |
| chr5:129,480,973–129,482,051 | 21.1 kb | Distal (>10kb) Multiome | 217 | |
| chr5:129,671,939–129,672,825 | 212.0 kb | Distal (>10kb) Multiome | 238 | |
| chr5:131,170,393–131,171,717 | 1710.6 kb | Distal (>10kb) Multiome HiCAR | 780 |
Genomic view of the ADAMTS19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.