This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:5,078,132–5,079,034 | 61.6 kb | Distal (>10kb) Multiome | 171 | |
| chr5:5,139,356–5,140,841 | 215 bp | At TSS Multiome | 364 | |
| chr5:5,141,769–5,141,955 | 1.4 kb | Proximal (<10kb) | 95 | |
| chr5:5,179,195–5,180,337 | 39.5 kb | Distal (>10kb) Multiome | 139 | |
| chr5:5,182,894–5,183,828 | 43.1 kb | Distal (>10kb) Multiome | 303 | |
| chr5:5,198,807–5,199,844 | 58.9 kb | Distal (>10kb) Multiome | 128 | |
| chr5:5,270,819–5,272,461 | 131.1 kb | Distal (>10kb) Multiome | 448 | |
| chr5:5,421,006–5,423,420 | 282.1 kb | Distal (>10kb) Multiome | 913 |
Genomic view of the ADAMTS16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.