ADAM15
ADAM metallopeptidase domain 15 | MDC15

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Developmental clusters: GC3
Biological processes 36 terms
SH3 domain binding (GO:0017124)acrosomal vesicle (GO:0001669)adherens junction (GO:0005912)apoptotic process (GO:0006915)cell surface (GO:0009986)cell-matrix adhesion (GO:0007160)cellular response to phorbol 13-acetate 12-myristate (GO:1904628)endomembrane system (GO:0012505)extracellular exosome (GO:0070062)extracellular matrix disassembly (GO:0022617)extracellular region (GO:0005576)immune response to tumor cell (GO:0002418)immunoglobulin receptor binding (GO:0034987)innate immune response (GO:0045087)innate immune response (GO:0045087)integrin binding (GO:0005178)integrin binding (GO:0005178)integrin-mediated signaling pathway (GO:0007229)integrin-mediated signaling pathway (GO:0007229)male gonad development (GO:0008584)metalloendopeptidase activity (GO:0004222)metalloendopeptidase activity (GO:0004222)metalloendopeptidase activity (GO:0004222)metallopeptidase activity (GO:0008237)metallopeptidase activity (GO:0008237)metallopeptidase activity (GO:0008237)motile cilium (GO:0031514)negative regulation of cell growth (GO:0030308)negative regulation of cell migration (GO:0030336)negative regulation of cell-matrix adhesion (GO:0001953)plasma membrane (GO:0005886)protein binding (GO:0005515)proteolysis (GO:0006508)proteolysis (GO:0006508)response to hypobaric hypoxia (GO:1990910)tissue regeneration (GO:0042246)
Expression (TPM)
ADAM15 — as a Regulated Gene

TFs regulating ADAM15 0 TFs

Transcription factors with Perturb-seq knockdown data for ADAM15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAM15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ADAM15

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAM15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:154,870,031–154,870,680 181.0 kb Distal (>10kb) Multiome 300
chr1:154,936,148–154,937,752 114.4 kb Distal (>10kb) Multiome 1149
chr1:154,955,571–154,956,925 95.1 kb Distal (>10kb) Multiome 504
chr1:154,961,269–154,962,529 89.6 kb Distal (>10kb) Multiome 985
chr1:154,970,161–154,971,641 80.4 kb Distal (>10kb) Multiome 535
chr1:154,972,362–154,975,914 76.8 kb Distal (>10kb) Multiome 1085
chr1:154,982,968–154,983,632 68.1 kb Distal (>10kb) Multiome 693
chr1:154,998,961–155,004,423 52.0 kb Distal (>10kb) Multiome 1210
chr1:155,017,084–155,017,941 33.8 kb Distal (>10kb) Multiome HiCAR 1003
chr1:155,044,973–155,045,153 6.1 kb Proximal (<10kb) 319
chr1:155,050,292–155,052,078 123 bp At TSS Multiome 948
chr1:155,061,415–155,064,552 10.4 kb Distal (>10kb) Multiome 860
chr1:155,070,748–155,071,423 19.8 kb Distal (>10kb) Multiome 542
chr1:155,078,524–155,079,535 27.5 kb Distal (>10kb) Multiome 397
chr1:155,079,852–155,081,529 29.6 kb Distal (>10kb) Multiome 539
chr1:155,084,373–155,086,501 33.7 kb Distal (>10kb) Multiome 865
chr1:155,091,315–155,091,900 40.3 kb Distal (>10kb) Multiome 594
chr1:155,126,247–155,126,903 75.0 kb Distal (>10kb) Multiome 776
chr1:155,127,607–155,128,120 76.5 kb Distal (>10kb) Multiome 578
chr1:155,135,100–155,136,750 84.5 kb Distal (>10kb) Multiome 938
chr1:155,166,847–155,168,170 116.5 kb Distal (>10kb) Multiome 622
chr1:155,172,629–155,174,979 123.2 kb Distal (>10kb) Multiome 903
chr1:155,192,921–155,194,099 142.2 kb Distal (>10kb) Multiome 755
chr1:155,194,230–155,195,403 143.5 kb Distal (>10kb) Multiome 753
chr1:155,196,127–155,196,592 145.1 kb Distal (>10kb) Multiome 97
chr1:155,207,822–155,209,789 157.7 kb Distal (>10kb) Multiome 826
chr1:155,227,312–155,228,116 176.4 kb Distal (>10kb) Multiome 688
chr1:155,244,103–155,245,349 193.5 kb Distal (>10kb) Multiome 900
chr1:155,250,356–155,251,199 199.5 kb Distal (>10kb) Multiome 605
chr1:155,255,032–155,255,921 204.2 kb Distal (>10kb) Multiome 661
chr1:155,261,679–155,262,788 211.0 kb Distal (>10kb) Multiome 921
chr1:155,272,928–155,274,098 222.2 kb Distal (>10kb) Multiome 768
chr1:155,276,933–155,278,884 226.0 kb Distal (>10kb) Multiome 749
chr1:155,308,291–155,309,348 257.4 kb Distal (>10kb) Multiome 934
chr1:155,320,564–155,321,470 269.6 kb Distal (>10kb) Multiome 341
chr1:155,322,680–155,325,643 273.1 kb Distal (>10kb) Multiome 979

Genome Browser

Genomic view of the ADAM15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:154,860,031 – 155,335,643
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact