Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ACYP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACYP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACYP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:53,767,422–53,768,367 | 203.2 kb | Distal (>10kb) Multiome | 710 | |
| chr2:53,786,365–53,787,886 | 184.1 kb | Distal (>10kb) Multiome | 999 | |
| chr2:53,859,343–53,860,396 | 111.2 kb | Distal (>10kb) Multiome | 238 | |
| chr2:53,970,071–53,971,956 | 44 bp | At TSS Multiome | 992 | |
| chr2:53,973,080–53,973,900 | 2.5 kb | Proximal (<10kb) Multiome | 37 | |
| chr2:54,087,898–54,089,384 | 117.3 kb | Distal (>10kb) Multiome | 214 | |
| chr2:54,115,347–54,116,192 | 144.7 kb | Distal (>10kb) Multiome | 1060 |
Genomic view of the ACYP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.