Involved in several processes, including DNA repair; chromatin remodeling; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACTR5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACTR5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACTR5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:38,472,312–38,473,463 | 275.7 kb | Distal (>10kb) Multiome | 898 | |
| chr20:38,607,297–38,607,885 | 140.9 kb | Distal (>10kb) Multiome | 125 | |
| chr20:38,612,897–38,613,663 | 135.3 kb | Distal (>10kb) Multiome | 78 | |
| chr20:38,646,005–38,646,460 | 102.2 kb | Distal (>10kb) Multiome | 567 | |
| chr20:38,673,746–38,675,067 | 74.0 kb | Distal (>10kb) Multiome | 446 | |
| chr20:38,725,938–38,726,412 | 22.4 kb | Distal (>10kb) Multiome | 218 | |
| chr20:38,727,220–38,727,813 | 21.1 kb | Distal (>10kb) Multiome | 231 | |
| chr20:38,730,955–38,731,938 | 17.1 kb | Distal (>10kb) Multiome | 646 | |
| chr20:38,747,701–38,748,998 | 218 bp | At TSS Multiome | 909 | |
| chr20:38,804,662–38,806,744 | 56.4 kb | Distal (>10kb) Multiome | 532 | |
| chr20:38,825,817–38,826,402 | 77.7 kb | Distal (>10kb) Multiome | 502 | |
| chr20:38,893,515–38,894,286 | 145.5 kb | Distal (>10kb) Multiome | 473 | |
| chr20:38,925,940–38,927,103 | 177.8 kb | Distal (>10kb) Multiome | 989 | |
| chr20:38,961,917–38,962,858 | 213.8 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:40,687,310–40,690,886 | 1940.8 kb | Distal (>10kb) Multiome HiCAR | 846 |
Genomic view of the ACTR5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.