The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACTR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACTR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACTR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:65,055,719–65,057,013 | 171.4 kb | Distal (>10kb) Multiome | 991 | |
| chr2:65,077,079–65,077,793 | 150.3 kb | Distal (>10kb) Multiome | 133 | |
| chr2:65,129,449–65,131,116 | 97.4 kb | Distal (>10kb) Multiome | 977 | |
| chr2:65,227,140–65,228,436 | 37 bp | At TSS Multiome | 971 | |
| chr2:65,331,150–65,331,849 | 103.7 kb | Distal (>10kb) Multiome | 47 | |
| chr2:65,350,820–65,351,607 | 123.5 kb | Distal (>10kb) Multiome | 223 | |
| chr2:65,430,513–65,433,282 | 204.9 kb | Distal (>10kb) Multiome | 1068 | |
| chr2:65,435,385–65,436,948 | 208.2 kb | Distal (>10kb) Multiome | 1075 | |
| chr2:65,437,559–65,438,643 | 210.3 kb | Distal (>10kb) Multiome | 402 |
Genomic view of the ACTR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.