ACOX1
acyl-CoA oxidase 1 | PALMCOX

The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Member of: DE-4 Developmental clusters: GC6
Biological processes 46 terms
FAD binding (GO:0071949)FAD binding (GO:0071949)PDZ domain binding (GO:0030165)acyl-CoA oxidase activity (GO:0003997)acyl-CoA oxidase activity (GO:0003997)acyl-CoA oxidase activity (GO:0003997)acyl-CoA oxidase activity (GO:0003997)cholesterol homeostasis (GO:0042632)cytosol (GO:0005829)fatty acid beta-oxidation (GO:0006635)fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)fatty acid binding (GO:0005504)fatty acid binding (GO:0005504)fatty acid catabolic process (GO:0009062)fatty acid metabolic process (GO:0006631)fatty acid oxidation (GO:0019395)fatty acid oxidation (GO:0019395)flavin adenine dinucleotide binding (GO:0050660)flavin adenine dinucleotide binding (GO:0050660)generation of precursor metabolites and energy (GO:0006091)hydrogen peroxide biosynthetic process (GO:0050665)lipid homeostasis (GO:0055088)lipid homeostasis (GO:0055088)lipid metabolic process (GO:0006629)long-chain fatty acyl-CoA oxidase activity (GO:0120524)long-chain fatty acyl-CoA oxidase activity (GO:0120524)long-chain fatty acyl-CoA oxidase activity (GO:0120524)membrane (GO:0016020)oxidoreductase activity (GO:0016491)oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)peroxisomal matrix (GO:0005782)peroxisomal matrix (GO:0005782)peroxisome (GO:0005777)peroxisome (GO:0005777)peroxisome (GO:0005777)peroxisome (GO:0005777)peroxisome fission (GO:0016559)prostaglandin metabolic process (GO:0006693)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)very long-chain fatty acid beta-oxidation (GO:0140493)very long-chain fatty acid metabolic process (GO:0000038)very long-chain fatty acid metabolic process (GO:0000038)
Expression (TPM)
ACOX1 — as a Regulated Gene

TFs regulating ACOX1 0 TFs

Transcription factors with Perturb-seq knockdown data for ACOX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACOX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ACOX1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACOX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:75,720,933–75,721,693 257.8 kb Distal (>10kb) Multiome 509
chr17:75,753,534–75,754,285 225.3 kb Distal (>10kb) Multiome 699
chr17:75,764,621–75,765,674 214.0 kb Distal (>10kb) Multiome 769
chr17:75,778,786–75,780,191 199.3 kb Distal (>10kb) Multiome 1118
chr17:75,784,060–75,785,640 194.3 kb Distal (>10kb) Multiome 1176
chr17:75,827,420–75,828,293 151.4 kb Distal (>10kb) Multiome 404
chr17:75,830,158–75,830,695 148.8 kb Distal (>10kb) Multiome 190
chr17:75,832,912–75,833,396 146.0 kb Distal (>10kb) Multiome 104
chr17:75,845,103–75,845,662 133.8 kb Distal (>10kb) Multiome 703
chr17:75,854,955–75,856,363 123.7 kb Distal (>10kb) Multiome 1038
chr17:75,877,486–75,878,900 101.1 kb Distal (>10kb) Multiome 884
chr17:75,896,392–75,897,754 82.2 kb Distal (>10kb) Multiome 831
chr17:75,904,371–75,905,532 74.1 kb Distal (>10kb) Multiome 1045
chr17:75,940,734–75,941,471 38.1 kb Distal (>10kb) Multiome 982
chr17:75,978,646–75,980,102 203 bp At TSS Multiome 1090
chr17:75,983,292–75,984,226 4.7 kb Proximal (<10kb) Multiome 236
chr17:76,014,120–76,014,727 35.2 kb Distal (>10kb) Multiome 489
chr17:76,029,331–76,030,158 50.5 kb Distal (>10kb) Multiome 722
chr17:76,072,173–76,072,853 93.4 kb Distal (>10kb) Multiome 893
chr17:76,074,414–76,075,796 95.5 kb Distal (>10kb) Multiome 280
chr17:76,103,272–76,104,343 124.6 kb Distal (>10kb) Multiome 798
chr17:76,121,142–76,122,265 142.4 kb Distal (>10kb) Multiome 689
chr17:76,132,004–76,133,216 153.6 kb Distal (>10kb) Multiome 536
chr17:76,135,151–76,135,652 156.1 kb Distal (>10kb) Multiome 104
chr17:76,141,012–76,141,958 162.2 kb Distal (>10kb) Multiome 616
chr17:76,240,278–76,241,169 261.5 kb Distal (>10kb) Multiome 560
chr17:76,264,834–76,266,286 286.0 kb Distal (>10kb) Multiome 868

Genome Browser

Genomic view of the ACOX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:75,710,933 – 76,276,286
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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