Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for ACIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,821,826–22,823,530 | 248.7 kb | Distal (>10kb) Multiome | 649 | |
| chr14:22,829,704–22,830,328 | 241.6 kb | Distal (>10kb) Multiome | 871 | |
| chr14:22,836,107–22,837,017 | 235.1 kb | Distal (>10kb) Multiome | 320 | |
| chr14:22,852,845–22,853,709 | 218.3 kb | Distal (>10kb) Multiome | 788 | |
| chr14:22,870,967–22,873,202 | 200.0 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 188.4 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 184.4 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 152.2 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 142.1 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 114.5 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 88.9 kb | Distal (>10kb) Multiome HiCAR | 935 | |
| chr14:23,006,674–23,007,583 | 64.4 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 50.6 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 30.1 kb | Distal (>10kb) Multiome HiCAR | 83 | |
| chr14:23,154,159–23,154,639 | 82.9 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 89.8 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,182,495–23,182,942 | 111.2 kb | Distal (>10kb) Multiome | 139 | |
| chr14:23,237,732–23,238,192 | 166.3 kb | Distal (>10kb) Multiome HiCAR | 536 | |
| chr14:23,285,641–23,286,830 | 214.7 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 230.1 kb | Distal (>10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 235.2 kb | Distal (>10kb) Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 249.7 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 281.3 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 294.9 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the ACIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.