Enables N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Involved in several processes, including myelination; positive regulation of cell population proliferation; and sphingolipid metabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. Biomarker of hepatocellular carcinoma and metabolic dysfunction-associated steatohepatitis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACER3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACER3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACER3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:76,624,568–76,625,315 | 235.9 kb | Distal (>10kb) Multiome | 105 | |
| chr11:76,670,486–76,671,227 | 190.1 kb | Distal (>10kb) Multiome | 303 | |
| chr11:76,733,962–76,736,172 | 126.8 kb | Distal (>10kb) Multiome | 353 | |
| chr11:76,758,769–76,759,574 | 101.7 kb | Distal (>10kb) Multiome | 99 | |
| chr11:76,770,356–76,771,447 | 90.1 kb | Distal (>10kb) Multiome | 371 | |
| chr11:76,782,794–76,784,887 | 76.7 kb | Distal (>10kb) Multiome | 929 | |
| chr11:76,787,865–76,789,130 | 72.4 kb | Distal (>10kb) Multiome | 462 | |
| chr11:76,798,746–76,799,610 | 61.6 kb | Distal (>10kb) Multiome | 661 | |
| chr11:76,807,112–76,807,736 | 53.4 kb | Distal (>10kb) Multiome | 373 | |
| chr11:76,860,430–76,861,513 | 89 bp | At TSS Multiome | 706 | |
| chr11:77,039,527–77,040,269 | 178.9 kb | Distal (>10kb) Multiome | 214 | |
| chr11:77,066,090–77,067,711 | 205.9 kb | Distal (>10kb) Multiome | 664 | |
| chr11:77,091,010–77,091,507 | 230.4 kb | Distal (>10kb) Multiome | 344 | |
| chr11:77,126,985–77,127,575 | 266.4 kb | Distal (>10kb) Multiome | 458 | |
| chr11:77,147,671–77,148,349 | 287.1 kb | Distal (>10kb) Multiome | 172 |
Genomic view of the ACER3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.