Enables fatty-acyl-CoA binding activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACBD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACBD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACBD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:180,228,833–180,231,894 | 272.8 kb | Distal (>10kb) Multiome | 657 | |
| chr1:180,234,382–180,235,870 | 267.8 kb | Distal (>10kb) Multiome | 241 | |
| chr1:180,501,987–180,503,224 | 34 bp | At TSS Multiome | 1104 | |
| chr1:180,631,586–180,632,828 | 129.4 kb | Distal (>10kb) Multiome | 843 | |
| chr1:180,639,769–180,640,641 | 137.4 kb | Distal (>10kb) Multiome | 216 | |
| chr1:180,922,741–180,923,870 | 420.8 kb | Distal (>10kb) Multiome HiCAR | 265 | |
| chr1:181,142,277–181,142,792 | 640.0 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr1:181,179,406–181,181,016 | 677.8 kb | Distal (>10kb) Multiome HiCAR | 389 |
Genomic view of the ACBD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.