ACBD4

acyl-CoA binding domain containing 4 | FLJ13322

This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Biological processes 5 terms

cytoplasm (GO:0005737)fatty acid metabolic process (GO:0006631)fatty-acyl-CoA binding (GO:0000062)fatty-acyl-CoA binding (GO:0000062)protein binding (GO:0005515)

Expression (TPM)

TFs regulating ACBD4 0 TFs

Transcription factors with Perturb-seq knockdown data for ACBD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACBD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ACBD4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACBD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:44,899,009–44,900,053	236.0 kb	Distal (>10kb) Multiome	987
chr17:44,911,165–44,911,786	224.3 kb	Distal (>10kb) Multiome	412
chr17:44,947,322–44,948,161	187.9 kb	Distal (>10kb) Multiome	891
chr17:44,966,864–44,969,160	167.2 kb	Distal (>10kb) Multiome	526
chr17:44,987,181–44,987,616	148.1 kb	Distal (>10kb) Multiome	93
chr17:45,021,768–45,022,248	113.6 kb	Distal (>10kb) Multiome	739
chr17:45,051,210–45,051,755	84.1 kb	Distal (>10kb) Multiome	771
chr17:45,060,587–45,061,694	74.5 kb	Distal (>10kb) Multiome	979
chr17:45,131,590–45,133,655	2.3 kb	Proximal (<10kb) Multiome	898
chr17:45,135,189–45,136,052	126 bp	At TSS Multiome	930
chr17:45,143,207–45,145,183	8.2 kb	Proximal (<10kb) Multiome	308
chr17:45,147,066–45,150,271	11.7 kb	Distal (>10kb) Multiome	1345
chr17:45,160,688–45,162,340	26.0 kb	Distal (>10kb) Multiome	1200
chr17:45,197,493–45,198,189	62.3 kb	Distal (>10kb) Multiome HiCAR	835
chr17:45,241,380–45,242,217	106.2 kb	Distal (>10kb) Multiome	131
chr17:45,246,828–45,248,615	112.1 kb	Distal (>10kb) Multiome	858
chr17:45,261,690–45,262,406	126.4 kb	Distal (>10kb) Multiome	234
chr17:45,316,202–45,317,910	181.5 kb	Distal (>10kb) Multiome	857
chr17:45,334,174–45,334,847	198.7 kb	Distal (>10kb) Multiome	149
chr17:45,371,481–45,372,140	236.2 kb	Distal (>10kb) Multiome	704
chr17:45,395,009–45,395,645	259.6 kb	Distal (>10kb) Multiome	482
chr17:45,404,953–45,406,129	269.8 kb	Distal (>10kb) Multiome	244
chr17:45,425,403–45,426,061	290.1 kb	Distal (>10kb) Multiome	506
chr17:45,427,967–45,428,575	292.6 kb	Distal (>10kb) Multiome	454
chr17:45,429,511–45,430,237	294.1 kb	Distal (>10kb) Multiome	190
chr17:45,431,253–45,432,633	296.1 kb	Distal (>10kb) Multiome	435
chr17:46,770,710–46,773,968	1636.2 kb	Distal (>10kb) Multiome HiCAR	1101

Genome Browser

Genomic view of the ACBD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.