ACADVL
acyl-CoA dehydrogenase very long chain | ACAD6, LCACD, VLCAD

The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Developmental clusters: GC6
Biological processes 37 terms
acyl-CoA dehydrogenase activity (GO:0003995)acyl-CoA dehydrogenase activity (GO:0003995)energy derivation by oxidation of organic compounds (GO:0015980)epithelial cell differentiation (GO:0030855)fatty acid beta-oxidation (GO:0006635)fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539)fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539)fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539)fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539)fatty-acyl-CoA binding (GO:0000062)flavin adenine dinucleotide binding (GO:0050660)flavin adenine dinucleotide binding (GO:0050660)identical protein binding (GO:0042802)long-chain fatty acyl-CoA dehydrogenase activity (GO:0004466)long-chain fatty acyl-CoA dehydrogenase activity (GO:0004466)long-chain fatty acyl-CoA dehydrogenase activity (GO:0004466)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial membrane (GO:0031966)mitochondrial membrane (GO:0031966)mitochondrial nucleoid (GO:0042645)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of fatty acid biosynthetic process (GO:0045717)negative regulation of fatty acid biosynthetic process (GO:0045717)negative regulation of fatty acid oxidation (GO:0046322)negative regulation of fatty acid oxidation (GO:0046322)oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)protein binding (GO:0005515)regulation of cholesterol metabolic process (GO:0090181)regulation of cholesterol metabolic process (GO:0090181)temperature homeostasis (GO:0001659)temperature homeostasis (GO:0001659)very-long-chain fatty acyl-CoA dehydrogenase activity (GO:0017099)very-long-chain fatty acyl-CoA dehydrogenase activity (GO:0017099)very-long-chain fatty acyl-CoA dehydrogenase activity (GO:0017099)
Expression (TPM)
ACADVL — as a Regulated Gene

TFs regulating ACADVL 0 TFs

Transcription factors with Perturb-seq knockdown data for ACADVL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACADVL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ACADVL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACADVL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:6,995,886–6,996,299 223.9 kb Distal (>10kb) Multiome 124
chr17:7,012,245–7,012,890 207.4 kb Distal (>10kb) Multiome 804
chr17:7,014,335–7,015,213 205.1 kb Distal (>10kb) Multiome 842
chr17:7,021,831–7,024,265 196.0 kb Distal (>10kb) Multiome 614
chr17:7,035,527–7,036,637 183.9 kb Distal (>10kb) Multiome 791
chr17:7,132,532–7,133,109 87.1 kb Distal (>10kb) Multiome 312
chr17:7,177,263–7,177,909 42.4 kb Distal (>10kb) Multiome 453
chr17:7,204,820–7,205,551 14.8 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 11.7 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 5.4 kb Proximal (<10kb) Multiome 737
chr17:7,217,583–7,217,952 1.9 kb Proximal (<10kb) 180
chr17:7,219,603–7,220,515 32 bp At TSS Multiome 793
chr17:7,233,847–7,235,210 14.6 kb Distal (>10kb) Multiome 1020
chr17:7,237,531–7,238,757 18.1 kb Distal (>10kb) Multiome 502
chr17:7,238,867–7,240,155 19.8 kb Distal (>10kb) Multiome 783
chr17:7,241,494–7,243,462 23.2 kb Distal (>10kb) Multiome 1037
chr17:7,251,263–7,252,962 32.3 kb Distal (>10kb) Multiome 985
chr17:7,260,746–7,263,748 42.7 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 61.8 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 74.9 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 76.7 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 87.5 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 95.4 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 109.6 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 130.4 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 132.2 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 136.4 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 164.3 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 174.8 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 184.5 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 217.2 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 218.4 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 220.8 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 225.7 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 235.8 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 259.6 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 264.6 kb Distal (>10kb) Multiome 1156

Genome Browser

Genomic view of the ACADVL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:6,985,886 – 7,495,576
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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