Predicted to be involved in regulation of actin filament-based process. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABRACL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABRACL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABRACL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:138,772,879–138,774,086 | 255.2 kb | Distal (>10kb) Multiome | 833 | |
| chr6:138,795,674–138,796,576 | 232.7 kb | Distal (>10kb) Multiome | 181 | |
| chr6:138,817,772–138,818,464 | 210.6 kb | Distal (>10kb) Multiome | 321 | |
| chr6:138,890,955–138,892,013 | 137.3 kb | Distal (>10kb) Multiome | 99 | |
| chr6:138,987,166–138,988,932 | 40.5 kb | Distal (>10kb) Multiome | 1012 | |
| chr6:139,010,370–139,011,354 | 17.8 kb | Distal (>10kb) Multiome | 168 | |
| chr6:139,027,553–139,028,166 | 577 bp | At TSS | 283 | |
| chr6:139,028,353–139,030,017 | 10 bp | At TSS Multiome | 798 | |
| chr6:139,134,756–139,136,229 | 106.3 kb | Distal (>10kb) Multiome | 714 | |
| chr6:139,219,088–139,219,883 | 190.7 kb | Distal (>10kb) Multiome | 525 | |
| chr6:139,313,822–139,314,248 | 285.2 kb | Distal (>10kb) Multiome | 100 |
Genomic view of the ABRACL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.