Enables monoacylglycerol lipase activity. Involved in acylglycerol catabolic process. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ABHD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:57,969,842–57,970,308 | 267.5 kb | Distal (>10kb) Multiome | 332 | |
| chr3:57,992,220–57,993,259 | 244.9 kb | Distal (>10kb) Multiome | 382 | |
| chr3:57,998,619–57,999,287 | 238.7 kb | Distal (>10kb) Multiome | 336 | |
| chr3:58,002,992–58,003,441 | 234.3 kb | Distal (>10kb) Multiome | 128 | |
| chr3:58,006,378–58,007,041 | 230.8 kb | Distal (>10kb) Multiome | 155 | |
| chr3:58,007,913–58,009,633 | 229.2 kb | Distal (>10kb) Multiome | 747 | |
| chr3:58,021,094–58,022,164 | 216.0 kb | Distal (>10kb) Multiome | 478 | |
| chr3:58,034,682–58,035,269 | 202.5 kb | Distal (>10kb) Multiome | 260 | |
| chr3:58,049,229–58,049,752 | 188.1 kb | Distal (>10kb) Multiome | 668 | |
| chr3:58,177,450–58,178,460 | 59.6 kb | Distal (>10kb) Multiome | 551 | |
| chr3:58,187,606–58,188,058 | 49.6 kb | Distal (>10kb) Multiome | 377 | |
| chr3:58,217,189–58,217,783 | 20.1 kb | Distal (>10kb) Multiome | 545 | |
| chr3:58,222,267–58,222,780 | 15.0 kb | Distal (>10kb) Multiome | 115 | |
| chr3:58,236,918–58,238,686 | 62 bp | At TSS Multiome | 727 | |
| chr3:58,305,855–58,306,746 | 68.8 kb | Distal (>10kb) Multiome | 875 | |
| chr3:58,332,558–58,333,709 | 95.4 kb | Distal (>10kb) Multiome | 705 | |
| chr3:58,433,383–58,434,404 | 196.3 kb | Distal (>10kb) Multiome | 938 | |
| chr3:58,434,510–58,435,588 | 197.7 kb | Distal (>10kb) Multiome | 226 | |
| chr3:58,441,570–58,442,309 | 204.4 kb | Distal (>10kb) Multiome | 65 | |
| chr3:58,450,170–58,450,919 | 213.1 kb | Distal (>10kb) Multiome | 20 | |
| chr3:58,463,546–58,463,974 | 226.3 kb | Distal (>10kb) Multiome | 479 | |
| chr3:58,470,966–58,471,873 | 234.0 kb | Distal (>10kb) Multiome | 742 | |
| chr3:58,491,060–58,492,581 | 254.4 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the ABHD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.