This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ABHD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:21,599,940–21,601,513 | 104.0 kb | Distal (>10kb) Multiome | 1132 | |
| chr18:21,611,922–21,612,689 | 92.5 kb | Distal (>10kb) Multiome | 1050 | |
| chr18:21,703,851–21,705,209 | 30 bp | At TSS Multiome | 801 | |
| chr18:21,740,314–21,741,964 | 36.0 kb | Distal (>10kb) Multiome | 803 | |
| chr18:21,754,780–21,755,646 | 50.4 kb | Distal (>10kb) Multiome | 105 | |
| chr18:21,912,423–21,913,408 | 208.1 kb | Distal (>10kb) Multiome | 73 | |
| chr18:21,933,673–21,935,412 | 229.9 kb | Distal (>10kb) Multiome | 335 | |
| chr18:21,990,759–21,991,669 | 286.5 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the ABHD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.