Enables hydrolase activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABHD14B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD14B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD14B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:50,336,856–50,338,227 | 1636.4 kb | Distal (>10kb) Multiome HiCAR | 952 | |
| chr3:50,567,311–50,568,123 | 1406.3 kb | Distal (>10kb) Multiome HiCAR | 376 | |
| chr3:50,568,824–50,569,934 | 1404.7 kb | Distal (>10kb) Multiome HiCAR | 901 | |
| chr3:51,681,945–51,682,394 | 291.8 kb | Distal (>10kb) Multiome | 291 | |
| chr3:51,706,614–51,707,579 | 267.0 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr3:51,798,234–51,798,899 | 175.4 kb | Distal (>10kb) Multiome | 120 | |
| chr3:51,800,441–51,801,024 | 173.5 kb | Distal (>10kb) Multiome | 20 | |
| chr3:51,801,591–51,802,872 | 171.7 kb | Distal (>10kb) Multiome | 223 | |
| chr3:51,868,646–51,869,606 | 105.0 kb | Distal (>10kb) Multiome | 50 | |
| chr3:51,941,340–51,942,909 | 31.9 kb | Distal (>10kb) Multiome HiCAR | 890 | |
| chr3:51,955,723–51,956,827 | 17.5 kb | Distal (>10kb) Multiome | 289 | |
| chr3:51,967,071–51,968,598 | 6.5 kb | Proximal (<10kb) Multiome | 581 | |
| chr3:51,973,571–51,975,404 | 22 bp | At TSS Multiome | 886 | |
| chr3:51,982,506–51,983,633 | 9.2 kb | Proximal (<10kb) Multiome | 933 | |
| chr3:51,990,597–51,991,772 | 17.0 kb | Distal (>10kb) Multiome | 145 | |
| chr3:51,995,468–51,996,121 | 21.9 kb | Distal (>10kb) Multiome | 938 | |
| chr3:52,001,516–52,001,992 | 27.7 kb | Distal (>10kb) Multiome | 448 | |
| chr3:52,055,881–52,058,048 | 83.4 kb | Distal (>10kb) Multiome | 937 | |
| chr3:52,128,194–52,128,700 | 154.4 kb | Distal (>10kb) Multiome | 376 | |
| chr3:52,153,766–52,155,196 | 180.6 kb | Distal (>10kb) Multiome | 896 | |
| chr3:52,197,554–52,198,856 | 224.1 kb | Distal (>10kb) Multiome | 731 | |
| chr3:52,238,767–52,239,716 | 265.2 kb | Distal (>10kb) Multiome | 763 | |
| chr3:52,245,446–52,246,450 | 271.9 kb | Distal (>10kb) Multiome | 553 | |
| chr3:52,277,664–52,279,184 | 304.7 kb | Distal (>10kb) Multiome | 844 |
Genomic view of the ABHD14B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.