The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for ABCG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:87,921,767–87,922,408 | 237.3 kb | Distal (>10kb) Multiome | 58 | |
| chr4:88,006,620–88,008,542 | 151.7 kb | Distal (>10kb) Multiome | 543 | |
| chr4:88,152,439–88,152,721 | 6.6 kb | Proximal (<10kb) | 23 | |
| chr4:88,158,357–88,159,406 | 350 bp | At TSS Multiome | 719 | |
| chr4:88,178,032–88,179,178 | 19.2 kb | Distal (>10kb) Multiome | 219 | |
| chr4:88,283,347–88,285,223 | 125.4 kb | Distal (>10kb) Multiome | 864 | |
| chr4:88,378,676–88,379,604 | 219.9 kb | Distal (>10kb) Multiome | 741 | |
| chr4:88,456,441–88,457,951 | 297.8 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the ABCG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.