The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ABCC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,143,296–43,143,802 | 283.9 kb | Distal (>10kb) Multiome | 638 | |
| chr6:43,170,289–43,172,815 | 256.3 kb | Distal (>10kb) Multiome | 1025 | |
| chr6:43,173,720–43,174,910 | 253.0 kb | Distal (>10kb) Multiome | 765 | |
| chr6:43,181,838–43,182,555 | 245.4 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 198.1 kb | Distal (>10kb) Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 180.3 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,267,244–43,268,167 | 159.9 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr6:43,285,054–43,285,508 | 142.2 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 118.7 kb | Distal (>10kb) Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 57.9 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 132 bp | At TSS Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 27.2 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 50.0 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 79.4 kb | Distal (>10kb) Multiome | 474 | |
| chr6:43,509,337–43,511,016 | 82.8 kb | Distal (>10kb) Multiome | 734 | |
| chr6:43,516,463–43,517,515 | 89.5 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 148.5 kb | Distal (>10kb) Multiome | 1044 | |
| chr6:43,628,488–43,630,447 | 202.7 kb | Distal (>10kb) Multiome | 1157 | |
| chr6:43,635,496–43,636,104 | 208.3 kb | Distal (>10kb) Multiome | 941 | |
| chr6:43,644,712–43,645,902 | 217.8 kb | Distal (>10kb) Multiome | 255 | |
| chr6:43,667,273–43,667,900 | 239.8 kb | Distal (>10kb) Multiome | 625 | |
| chr6:43,667,997–43,668,873 | 240.9 kb | Distal (>10kb) Multiome | 664 | |
| chr6:43,695,239–43,695,940 | 268.2 kb | Distal (>10kb) Multiome | 207 | |
| chr6:43,702,335–43,703,403 | 275.4 kb | Distal (>10kb) Multiome | 713 | |
| chr6:43,706,840–43,708,370 | 280.4 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the ABCC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.