The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for ABCB9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCB9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCB9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,751,194–122,751,767 | 215.1 kb | Distal (>10kb) Multiome | 128 | |
| chr12:122,752,332–122,753,299 | 213.7 kb | Distal (>10kb) Multiome | 978 | |
| chr12:122,774,223–122,774,865 | 191.9 kb | Distal (>10kb) Multiome | 445 | |
| chr12:122,834,656–122,836,128 | 131.1 kb | Distal (>10kb) Multiome | 514 | |
| chr12:122,895,832–122,896,391 | 70.4 kb | Distal (>10kb) Multiome | 774 | |
| chr12:122,965,963–122,966,953 | 57 bp | At TSS Multiome HiCAR | 576 | |
| chr12:122,974,115–122,975,704 | 8.4 kb | Proximal (<10kb) Multiome HiCAR | 889 | |
| chr12:122,980,138–122,981,155 | 14.2 kb | Distal (>10kb) Multiome | 817 | |
| chr12:123,049,639–123,050,104 | 83.3 kb | Distal (>10kb) Multiome | 45 | |
| chr12:123,150,285–123,151,740 | 184.6 kb | Distal (>10kb) Multiome | 487 | |
| chr12:123,232,511–123,233,923 | 266.7 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:123,269,375–123,269,864 | 303.2 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 304.8 kb | Distal (>10kb) Multiome | 488 |
Genomic view of the ABCB9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.