This gene encodes a member of the non-ribosome peptide syntesase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for AASDH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AASDH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AASDH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:56,323,870–56,324,663 | 63.1 kb | Distal (>10kb) Multiome | 70 | |
| chr4:56,386,710–56,387,993 | 74 bp | At TSS Multiome | 942 | |
| chr4:56,389,587–56,390,034 | 2.1 kb | Proximal (<10kb) | 165 | |
| chr4:56,434,804–56,437,263 | 48.5 kb | Distal (>10kb) Multiome | 1056 | |
| chr4:56,467,264–56,468,300 | 80.2 kb | Distal (>10kb) Multiome | 743 | |
| chr4:56,505,059–56,505,907 | 118.1 kb | Distal (>10kb) Multiome | 306 | |
| chr4:56,530,151–56,531,207 | 143.1 kb | Distal (>10kb) Multiome | 395 | |
| chr4:56,544,602–56,545,190 | 157.3 kb | Distal (>10kb) Multiome | 720 | |
| chr4:56,655,262–56,656,591 | 268.2 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the AASDH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.