Predicted to enable hydrolase activity. Predicted to be an extracellular matrix structural constituent. Involved in microfibril assembly. Located in microfibril. Implicated in thoracic aortic aneurysm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THSD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THSD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THSD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:70,853,264–70,854,729 | 261.3 kb | Distal (>10kb) Multiome | 472 | |
| chr15:70,891,888–70,893,094 | 222.9 kb | Distal (>10kb) Multiome | 794 | |
| chr15:71,085,589–71,086,284 | 29.5 kb | Distal (>10kb) Multiome | 153 | |
| chr15:71,114,270–71,114,604 | 865 bp | At TSS | 126 | |
| chr15:71,114,765–71,116,364 | 33 bp | At TSS Multiome | 625 | |
| chr15:71,337,320–71,337,809 | 222.0 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the THSD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.