Enables histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Predicted to act upstream of or within several processes, including glutamatergic synaptic transmission; regulation of peptidyl-tyrosine phosphorylation; and visual learning. Predicted to be located in cell surface; postsynapse; and presynaptic active zone. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ZZEF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZZEF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZZEF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,845,518–3,846,549 | 296.7 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 249.8 kb | Distal (>10kb) Multiome | 716 | |
| chr17:3,944,497–3,945,384 | 198.1 kb | Distal (>10kb) Multiome | 277 | |
| chr17:3,964,969–3,965,418 | 177.8 kb | Distal (>10kb) Multiome | 333 | |
| chr17:4,003,950–4,004,421 | 139.1 kb | Distal (>10kb) Multiome | 404 | |
| chr17:4,004,672–4,005,109 | 138.2 kb | Distal (>10kb) Multiome | 632 | |
| chr17:4,142,469–4,144,218 | 798 bp | At TSS Multiome | 1007 | |
| chr17:4,263,266–4,264,359 | 120.9 kb | Distal (>10kb) Multiome | 729 | |
| chr17:4,365,147–4,367,069 | 222.3 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the ZZEF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.