This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for ZW10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZW10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZW10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:113,314,281–113,315,117 | 459.1 kb | Distal (>10kb) Multiome HiCAR | 715 | |
| chr11:113,474,175–113,475,764 | 299.2 kb | Distal (>10kb) Multiome | 487 | |
| chr11:113,628,900–113,629,434 | 144.6 kb | Distal (>10kb) Multiome | 147 | |
| chr11:113,681,336–113,682,352 | 92.1 kb | Distal (>10kb) Multiome | 213 | |
| chr11:113,773,177–113,774,192 | 65 bp | At TSS Multiome | 794 | |
| chr11:113,849,620–113,850,143 | 76.3 kb | Distal (>10kb) Multiome | 178 | |
| chr11:113,874,813–113,876,131 | 101.9 kb | Distal (>10kb) Multiome | 847 | |
| chr11:113,974,802–113,975,612 | 201.5 kb | Distal (>10kb) Multiome | 340 | |
| chr11:114,035,962–114,036,615 | 262.6 kb | Distal (>10kb) Multiome | 488 | |
| chr11:114,058,960–114,061,502 | 285.9 kb | Distal (>10kb) Multiome | 421 |
Genomic view of the ZW10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.