Predicted to enable zinc ion binding activity. Involved in double-strand break repair via homologous recombination and protein stabilization. Part of Shu complex. Implicated in ovarian dysgenesis 10 and spermatogenic failure 71. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZSWIM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSWIM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSWIM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:15,944,340–15,945,587 | 54.6 kb | Distal (>10kb) Multiome | 765 | |
| chr17:15,966,252–15,966,749 | 33.1 kb | Distal (>10kb) Multiome | 334 | |
| chr17:15,999,147–16,000,454 | 56 bp | At TSS Multiome | 1029 | |
| chr17:16,214,816–16,216,252 | 215.9 kb | Distal (>10kb) Multiome | 888 | |
| chr17:16,217,055–16,217,691 | 217.6 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the ZSWIM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.