This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZSCAN25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSCAN25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSCAN25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,325,304–99,326,401 | 291.1 kb | Distal (>10kb) Multiome | 858 | |
| chr7:99,373,955–99,375,619 | 241.4 kb | Distal (>10kb) Multiome | 759 | |
| chr7:99,392,361–99,394,025 | 223.8 kb | Distal (>10kb) Multiome | 486 | |
| chr7:99,407,975–99,409,432 | 208.1 kb | Distal (>10kb) Multiome | 975 | |
| chr7:99,438,371–99,439,668 | 177.9 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,465,842–99,466,381 | 150.8 kb | Distal (>10kb) Multiome | 949 | |
| chr7:99,471,690–99,473,325 | 144.2 kb | Distal (>10kb) Multiome | 861 | |
| chr7:99,499,759–99,500,629 | 116.7 kb | Distal (>10kb) Multiome | 809 | |
| chr7:99,504,224–99,505,507 | 112.2 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,557,927–99,559,319 | 58.3 kb | Distal (>10kb) Multiome | 922 | |
| chr7:99,580,108–99,580,792 | 36.5 kb | Distal (>10kb) Multiome | 296 | |
| chr7:99,616,474–99,617,353 | 102 bp | At TSS Multiome | 1043 | |
| chr7:99,617,599–99,617,918 | 654 bp | At TSS | 53 | |
| chr7:99,693,257–99,693,867 | 76.6 kb | Distal (>10kb) Multiome | 518 | |
| chr7:99,839,578–99,840,069 | 222.9 kb | Distal (>10kb) Multiome | 85 | |
| chr7:100,015,387–100,016,069 | 398.7 kb | Distal (>10kb) Multiome HiCAR | 744 | |
| chr7:100,049,441–100,050,060 | 432.9 kb | Distal (>10kb) Multiome HiCAR | 800 |
Genomic view of the ZSCAN25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.