Transcription factors with Perturb-seq knockdown data for ZSCAN2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSCAN2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSCAN2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,570,159–84,571,300 | 63.0 kb | Distal (>10kb) Multiome | 730 | |
| chr15:84,587,808–84,588,502 | 45.8 kb | Distal (>10kb) Multiome | 357 | |
| chr15:84,600,331–84,601,554 | 33.0 kb | Distal (>10kb) Multiome HiCAR | 827 | |
| chr15:84,603,386–84,604,192 | 30.2 kb | Distal (>10kb) Multiome HiCAR | 119 | |
| chr15:84,630,983–84,631,898 | 2.7 kb | Proximal (<10kb) Multiome | 649 | |
| chr15:84,633,275–84,634,337 | 165 bp | At TSS Multiome | 621 | |
| chr15:84,653,715–84,654,595 | 20.4 kb | Distal (>10kb) Multiome | 788 | |
| chr15:84,657,788–84,658,916 | 24.4 kb | Distal (>10kb) Multiome | 591 | |
| chr15:84,715,472–84,717,226 | 82.3 kb | Distal (>10kb) Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 101.3 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 114.5 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 183.5 kb | Distal (>10kb) Multiome | 375 | |
| chr15:84,928,071–84,928,522 | 294.4 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the ZSCAN2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.