This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZRSR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZRSR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZRSR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:15,493,050–15,493,972 | 296.8 kb | Distal (>10kb) Multiome | 563 | |
| chrX:15,674,577–15,676,009 | 114.8 kb | Distal (>10kb) Multiome | 724 | |
| chrX:15,737,668–15,738,738 | 52.0 kb | Distal (>10kb) Multiome | 369 | |
| chrX:15,789,952–15,790,771 | 277 bp | At TSS Multiome | 531 | |
| chrX:15,854,233–15,855,558 | 64.8 kb | Distal (>10kb) Multiome | 706 | |
| chrX:15,874,284–15,875,274 | 84.6 kb | Distal (>10kb) Multiome | 139 |
Genomic view of the ZRSR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.