ZRANB1

zinc finger RANBP2-type containing 1 | TRABID

Enables K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. Is active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2

Biological processes 31 terms

K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)catalytic activity (GO:0003824)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)deubiquitinase activity (GO:0101005)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)polyubiquitin modification-dependent protein binding (GO:0031593)positive regulation of Wnt signaling pathway (GO:0030177)positive regulation of canonical Wnt signaling pathway (GO:0090263)protein K29-linked deubiquitination (GO:0035523)protein K33-linked deubiquitination (GO:1990168)protein K63-linked deubiquitination (GO:0070536)protein K63-linked deubiquitination (GO:0070536)protein binding (GO:0005515)protein deubiquitination (GO:0016579)protein deubiquitination (GO:0016579)protein deubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0071947)protein deubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0071947)

Expression (TPM)

TFs regulating ZRANB1 0 TFs

Transcription factors with Perturb-seq knockdown data for ZRANB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZRANB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZRANB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZRANB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:124,743,297–124,744,966	197.7 kb	Distal (>10kb) Multiome	546
chr10:124,791,269–124,792,470	150.3 kb	Distal (>10kb) Multiome	976
chr10:124,800,254–124,802,352	140.3 kb	Distal (>10kb) Multiome	821
chr10:124,916,459–124,917,959	25.3 kb	Distal (>10kb) Multiome	843
chr10:124,952,123–124,952,426	10.0 kb	Proximal (<10kb)	110
chr10:125,048,088–125,048,633	106.2 kb	Distal (>10kb) Multiome	344
chr10:125,151,246–125,153,639	209.9 kb	Distal (>10kb) Multiome	450
chr10:125,159,798–125,162,908	219.1 kb	Distal (>10kb) Multiome	658

Genome Browser

Genomic view of the ZRANB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.