The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for ZPR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZPR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZPR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:116,499,258–116,499,862 | 288.4 kb | Distal (>10kb) Multiome | 176 | |
| chr11:116,579,863–116,581,591 | 207.0 kb | Distal (>10kb) Multiome | 336 | |
| chr11:116,687,439–116,688,374 | 100.0 kb | Distal (>10kb) Multiome | 122 | |
| chr11:116,732,600–116,733,018 | 55.2 kb | Distal (>10kb) Multiome | 240 | |
| chr11:116,772,462–116,773,416 | 15.0 kb | Distal (>10kb) Multiome | 928 | |
| chr11:116,787,704–116,788,396 | 77 bp | At TSS Multiome | 597 | |
| chr11:116,791,118–116,791,887 | 3.4 kb | Proximal (<10kb) Multiome | 473 | |
| chr11:116,813,255–116,814,379 | 25.8 kb | Distal (>10kb) Multiome | 206 | |
| chr11:116,835,609–116,836,611 | 48.1 kb | Distal (>10kb) Multiome | 666 |
Genomic view of the ZPR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.