Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNRF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNRF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNRF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:28,679,491–28,680,261 | 203.7 kb | Distal (>10kb) Multiome | 374 | |
| chr22:28,741,336–28,742,751 | 141.7 kb | Distal (>10kb) Multiome | 926 | |
| chr22:28,772,518–28,773,373 | 110.8 kb | Distal (>10kb) Multiome | 796 | |
| chr22:28,800,006–28,801,035 | 83.0 kb | Distal (>10kb) Multiome | 829 | |
| chr22:28,882,670–28,884,893 | 197 bp | At TSS Multiome | 802 | |
| chr22:29,004,535–29,005,249 | 121.4 kb | Distal (>10kb) Multiome | 417 | |
| chr22:29,029,712–29,031,115 | 147.3 kb | Distal (>10kb) Multiome HiCAR | 773 | |
| chr22:29,071,484–29,071,874 | 188.0 kb | Distal (>10kb) Multiome | 332 | |
| chr22:29,072,494–29,074,480 | 189.4 kb | Distal (>10kb) Multiome | 537 |
Genomic view of the ZNRF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.