Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Involved in box C/D snoRNP assembly; protein complex oligomerization; and snoRNA localization. Located in extracellular exosome. Part of pre-snoRNP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNHIT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNHIT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNHIT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:85,307,937–85,308,862 | 400.2 kb | Distal (>10kb) Multiome HiCAR | 554 | |
| chr1:85,464,074–85,465,652 | 243.4 kb | Distal (>10kb) Multiome | 747 | |
| chr1:85,576,283–85,578,303 | 131.4 kb | Distal (>10kb) Multiome | 711 | |
| chr1:85,579,630–85,582,885 | 127.6 kb | Distal (>10kb) Multiome | 929 | |
| chr1:85,707,592–85,709,003 | 28 bp | At TSS Multiome | 872 | |
| chr1:85,975,608–85,977,180 | 267.8 kb | Distal (>10kb) Multiome | 166 |
Genomic view of the ZNHIT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.