Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNHIT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNHIT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNHIT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,844,075–64,845,264 | 272.9 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr11:64,846,953–64,847,598 | 270.4 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr11:64,877,434–64,879,352 | 238.9 kb | Distal (>10kb) Multiome | 980 | |
| chr11:64,887,785–64,888,374 | 229.6 kb | Distal (>10kb) Multiome | 633 | |
| chr11:64,916,057–64,917,940 | 200.3 kb | Distal (>10kb) Multiome | 873 | |
| chr11:64,924,041–64,924,916 | 193.3 kb | Distal (>10kb) Multiome | 808 | |
| chr11:64,971,835–64,972,454 | 145.5 kb | Distal (>10kb) Multiome | 265 | |
| chr11:65,013,538–65,014,838 | 103.7 kb | Distal (>10kb) Multiome | 980 | |
| chr11:65,027,243–65,027,944 | 90.1 kb | Distal (>10kb) Multiome | 851 | |
| chr11:65,040,595–65,041,884 | 76.6 kb | Distal (>10kb) Multiome | 838 | |
| chr11:65,083,636–65,084,788 | 33.4 kb | Distal (>10kb) Multiome | 898 | |
| chr11:65,095,834–65,097,052 | 21.2 kb | Distal (>10kb) Multiome | 1061 | |
| chr11:65,110,215–65,110,605 | 7.1 kb | Proximal (<10kb) | 344 | |
| chr11:65,111,466–65,113,404 | 5.8 kb | Proximal (<10kb) Multiome | 919 | |
| chr11:65,116,528–65,118,298 | 135 bp | At TSS Multiome | 973 | |
| chr11:65,121,474–65,122,848 | 4.6 kb | Proximal (<10kb) Multiome | 817 | |
| chr11:65,134,120–65,135,530 | 17.3 kb | Distal (>10kb) Multiome | 997 | |
| chr11:65,180,773–65,182,676 | 63.8 kb | Distal (>10kb) Multiome | 832 | |
| chr11:65,184,109–65,184,542 | 66.7 kb | Distal (>10kb) Multiome | 85 | |
| chr11:65,213,383–65,213,853 | 96.0 kb | Distal (>10kb) Multiome | 174 | |
| chr11:65,225,439–65,226,037 | 108.0 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 144.2 kb | Distal (>10kb) Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 197.1 kb | Distal (>10kb) Multiome | 803 | |
| chr11:65,333,360–65,334,372 | 216.2 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 237.0 kb | Distal (>10kb) Multiome | 677 | |
| chr11:65,386,320–65,387,097 | 269.0 kb | Distal (>10kb) Multiome | 757 | |
| chr11:65,416,383–65,417,015 | 298.9 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the ZNHIT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.