Predicted to enable GTPase activity and zinc chaperone activity. Involved in kidney development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNG1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNG1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNG1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:72,989–73,599 | 105.7 kb | Distal (>10kb) Multiome | 42 | |
| chr9:113,338–114,370 | 65.0 kb | Distal (>10kb) Multiome | 117 | |
| chr9:179,077–179,233 | at TSS | At TSS | 66 | |
| chr9:214,473–215,549 | 35.9 kb | Distal (>10kb) Multiome | 678 | |
| chr9:222,426–223,483 | 43.4 kb | Distal (>10kb) Multiome | 174 | |
| chr9:259,527–260,467 | 80.9 kb | Distal (>10kb) Multiome | 194 | |
| chr9:346,260–346,845 | 167.3 kb | Distal (>10kb) Multiome | 154 | |
| chr9:469,614–470,747 | 291.0 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the ZNG1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.