This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ZNF879. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF879 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF879, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:178,730,157–178,730,973 | 293.1 kb | Distal (>10kb) Multiome | 717 | |
| chr5:178,778,843–178,779,399 | 244.8 kb | Distal (>10kb) Multiome | 165 | |
| chr5:178,859,723–178,860,476 | 163.8 kb | Distal (>10kb) Multiome | 813 | |
| chr5:178,895,613–178,896,587 | 127.8 kb | Distal (>10kb) Multiome | 509 | |
| chr5:178,994,469–178,995,315 | 28.9 kb | Distal (>10kb) Multiome | 118 | |
| chr5:179,023,213–179,023,439 | 363 bp | At TSS | 33 | |
| chr5:179,023,550–179,024,208 | 12 bp | At TSS Multiome | 632 | |
| chr5:179,060,130–179,060,668 | 36.6 kb | Distal (>10kb) Multiome | 376 | |
| chr5:179,166,799–179,167,598 | 143.5 kb | Distal (>10kb) Multiome | 276 |
Genomic view of the ZNF879 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.