Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF84. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF84 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF84, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:132,761,549–132,762,490 | 275.3 kb | Distal (>10kb) Multiome | 760 | |
| chr12:132,828,453–132,829,499 | 208.3 kb | Distal (>10kb) Multiome | 930 | |
| chr12:132,887,106–132,888,371 | 149.7 kb | Distal (>10kb) Multiome | 840 | |
| chr12:132,907,962–132,909,233 | 128.8 kb | Distal (>10kb) Multiome | 481 | |
| chr12:132,955,400–132,956,621 | 81.1 kb | Distal (>10kb) Multiome | 715 | |
| chr12:132,986,063–132,986,840 | 51.1 kb | Distal (>10kb) Multiome | 840 | |
| chr12:133,036,951–133,037,971 | 50 bp | At TSS Multiome | 973 | |
| chr12:133,079,789–133,081,303 | 43.0 kb | Distal (>10kb) Multiome | 937 | |
| chr12:133,129,825–133,131,032 | 93.0 kb | Distal (>10kb) Multiome | 945 | |
| chr12:133,181,282–133,181,959 | 144.1 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the ZNF84 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.