Enables NuRD complex binding activity. Involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and telomere maintenance. Located in chromatin and chromosome, telomeric region. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF827. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF827 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF827, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:145,703,274–145,705,032 | 234.7 kb | Distal (>10kb) Multiome | 271 | |
| chr4:145,729,525–145,730,444 | 208.9 kb | Distal (>10kb) Multiome | 46 | |
| chr4:145,732,348–145,733,906 | 205.7 kb | Distal (>10kb) Multiome | 591 | |
| chr4:145,887,216–145,887,983 | 51.3 kb | Distal (>10kb) Multiome | 199 | |
| chr4:145,909,209–145,909,939 | 29.2 kb | Distal (>10kb) Multiome | 176 | |
| chr4:145,928,846–145,929,007 | 9.4 kb | Proximal (<10kb) | 8 | |
| chr4:145,934,495–145,934,848 | 3.6 kb | Proximal (<10kb) | 35 | |
| chr4:145,935,719–145,938,595 | 2.9 kb | Proximal (<10kb) Multiome | 694 | |
| chr4:145,938,677–145,939,163 | 151 bp | At TSS Multiome | 664 | |
| chr4:146,175,371–146,176,493 | 237.1 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the ZNF827 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.