This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause an X-linked form of intellectual disability (MRX45). Microduplication of a region of chromosome X including this gene has also been associated with other forms of intellectual disability. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ZNF81. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF81 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF81, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,556,126–47,556,602 | 280.6 kb | Distal (>10kb) Multiome | 278 | |
| chrX:47,560,759–47,561,636 | 275.7 kb | Distal (>10kb) Multiome | 638 | |
| chrX:47,619,457–47,620,174 | 217.0 kb | Distal (>10kb) Multiome | 643 | |
| chrX:47,623,578–47,624,031 | 213.0 kb | Distal (>10kb) Multiome | 183 | |
| chrX:47,650,269–47,651,363 | 186.1 kb | Distal (>10kb) Multiome | 552 | |
| chrX:47,658,568–47,659,484 | 177.9 kb | Distal (>10kb) Multiome | 753 | |
| chrX:47,836,213–47,837,023 | 241 bp | At TSS Multiome | 544 | |
| chrX:48,021,260–48,021,892 | 184.6 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chrX:48,071,368–48,072,042 | 234.9 kb | Distal (>10kb) Multiome | 269 | |
| chrX:48,475,845–48,476,469 | 639.3 kb | Distal (>10kb) Multiome HiCAR | 613 | |
| chrX:48,508,766–48,509,247 | 672.0 kb | Distal (>10kb) Multiome HiCAR | 400 |
Genomic view of the ZNF81 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.