Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF775. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF775 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF775, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:149,870,542–149,871,523 | 508.4 kb | Distal (>10kb) Multiome HiCAR | 81 | |
| chr7:149,872,817–149,874,446 | 505.4 kb | Distal (>10kb) Multiome HiCAR | 826 | |
| chr7:150,340,210–150,341,978 | 37.6 kb | Distal (>10kb) Multiome | 416 | |
| chr7:150,368,010–150,369,898 | 10.7 kb | Distal (>10kb) Multiome | 1082 | |
| chr7:150,374,450–150,374,918 | 4.4 kb | Proximal (<10kb) | 77 | |
| chr7:150,378,105–150,380,206 | 1.0 kb | Proximal (<10kb) Multiome | 966 | |
| chr7:150,383,391–150,384,626 | 4.6 kb | Proximal (<10kb) Multiome | 537 | |
| chr7:150,388,931–150,389,198 | 9.6 kb | Proximal (<10kb) | 545 | |
| chr7:150,401,607–150,402,937 | 22.9 kb | Distal (>10kb) Multiome | 307 | |
| chr7:150,404,616–150,406,417 | 26.1 kb | Distal (>10kb) Multiome | 952 |
Genomic view of the ZNF775 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.