The protein encoded by this gene contains C2H2 zinc finger domains. In some individuals, a CGG-repeat expansion from 5-22 repeats to 68-450 repeats has been identified in the first intron of this gene. This mutation is thought to effect the expression of this gene and it has been proposed that it may be associated with Autistic Spectrum Disorder. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ZNF713. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF713 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF713, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:55,657,601–55,658,293 | 229.6 kb | Distal (>10kb) Multiome | 209 | |
| chr7:55,886,966–55,887,754 | 24 bp | At TSS Multiome | 546 | |
| chr7:55,951,547–55,952,549 | 64.4 kb | Distal (>10kb) Multiome | 801 | |
| chr7:55,964,099–55,965,278 | 77.2 kb | Distal (>10kb) Multiome | 738 | |
| chr7:56,033,660–56,034,707 | 146.8 kb | Distal (>10kb) Multiome | 673 | |
| chr7:56,051,159–56,052,300 | 164.2 kb | Distal (>10kb) Multiome | 882 | |
| chr7:56,063,656–56,065,393 | 176.8 kb | Distal (>10kb) Multiome | 926 | |
| chr7:56,074,109–56,074,780 | 187.0 kb | Distal (>10kb) Multiome | 423 | |
| chr7:56,106,168–56,106,786 | 219.1 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the ZNF713 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.