Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of stem cell population maintenance. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF706. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF706 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF706, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:100,907,969–100,909,029 | 297.1 kb | Distal (>10kb) Multiome | 553 | |
| chr8:100,950,243–100,953,706 | 252.7 kb | Distal (>10kb) Multiome | 1156 | |
| chr8:101,041,585–101,042,308 | 163.8 kb | Distal (>10kb) Multiome | 191 | |
| chr8:101,078,982–101,079,657 | 126.4 kb | Distal (>10kb) Multiome | 157 | |
| chr8:101,080,237–101,081,347 | 124.7 kb | Distal (>10kb) Multiome | 546 | |
| chr8:101,126,053–101,127,200 | 79.0 kb | Distal (>10kb) Multiome | 618 | |
| chr8:101,137,220–101,137,790 | 68.2 kb | Distal (>10kb) Multiome | 578 | |
| chr8:101,204,668–101,206,670 | 50 bp | At TSS Multiome | 1036 | |
| chr8:101,409,180–101,410,550 | 204.0 kb | Distal (>10kb) Multiome | 211 | |
| chr8:101,437,099–101,437,572 | 231.6 kb | Distal (>10kb) Multiome | 336 | |
| chr8:101,491,954–101,492,859 | 286.6 kb | Distal (>10kb) Multiome | 341 | |
| chr8:101,493,007–101,494,548 | 288.3 kb | Distal (>10kb) Multiome | 334 | |
| chr8:101,501,153–101,501,741 | 295.7 kb | Distal (>10kb) Multiome | 308 |
Genomic view of the ZNF706 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.