This gene encodes a protein containing the krueppel associated box (KRAB) and zinc-finger domains, which may be involved in transcriptional regulation. Non-functional alleles of this gene are present in alternate genome assemblies including T2T-CHM13v1.1, resulting from a 'TG' deletion (rs61397759) which causes a frameshift and a premature stop codon. [provided by RefSeq, Sep 2022]
Transcription factors with Perturb-seq knockdown data for ZNF681. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF681 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF681, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:23,686,411–23,687,441 | 71.7 kb | Distal (>10kb) Multiome | 490 | |
| chr19:23,718,765–23,719,251 | 39.9 kb | Distal (>10kb) Multiome | 11 | |
| chr19:23,723,949–23,724,608 | 34.7 kb | Distal (>10kb) Multiome | 69 | |
| chr19:23,758,246–23,759,135 | 45 bp | At TSS Multiome | 349 | |
| chr19:23,762,593–23,763,893 | 4.2 kb | Proximal (<10kb) Multiome | 429 | |
| chr19:24,033,224–24,034,370 | 274.7 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the ZNF681 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.